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女性更要多吃水果蔬菜防癌

时间:2013年08月26日 信息来源:互联网 点击:

女性更要多吃水果蔬菜防癌

Fruit and Vegetable Intakes Are Associated with Lower Risk of Bladder Cancer among Women in the Multiethnic Cohort Study

          夏威夷大学癌症研究中间的Song-Yi Park博士和他的研究团队近日发现多食用水果和蔬菜可能降低女性患恶性膀胱癌的概率。该研究是Multiethnic Cohort (MEC)研究的一部分,MEC研究从1993年开始,目的是评估饮食,生活体例,遗传因素与癌症风险之间的关系。Park博士和他的研究团队在12.5年内收集了185,885位老年人的数据,其中581位患有恶性膀胱癌(152位女性和429位男性)。校正过其他致癌因素后,科学家发现食用水果和蔬菜最多的女性患膀胱癌的发病率是最低的。该研究预示摄入高剂量的维生素A,C和E的女性患膀胱癌的发病率最低。但是科学家没有发现水果,蔬菜摄入量与男性恶性膀胱癌之间的关系。Park博士称,我们的研究支撑了水果和蔬菜具有抗癌作用的假说,进一步的研究要揭示为什么摄入高剂量的水果和蔬菜仅能降低女性的癌症发病率,而不影响男性的发病率。

原文择要参阅:              Fruits and vegetables have been examined for their possible effects on the risk of bladder cancer, as they contain numerous nutrients, phytochemicals, and antioxidants with potentially anticarcinogenic properties. In a prospective analysis of 185,885 older adults participating in the Multiethnic Cohort Study, we examined whether the consumption of fruits and vegetables, or of nutrients concentrated in fruits and vegetables, was associated with bladder cancer risk. Cox proportional hazards models were used to calculate HRs and 95% CIs for bladder cancer in relation to dietary intakes. A total of 581 invasive bladder cancer cases (429 men and 152 women) were diagnosed over a mean follow-up period of 12.5 y. In women, total fruits and vegetables [HR = 0.35 (95% CI: 0.22, 0.56); highest vs. lowest quartile], total vegetables [HR = 0.49 (95% CI: 0.29, 0.83)], yellow-orange vegetables [HR = 0.48 (95% CI: 0.30, 0.77)], total fruits [HR = 0.54 (95% CI: 0.34, 0.85)], and citrus fruits [HR = 0.56 (95% CI: 0.34, 0.90)] were inversely associated with the risk of invasive bladder cancer in risk factor-adjusted models. In addition, women with the highest intakes of vitamins A, C, and E; the carotenoids α-carotene, β-carotene, and β-cryptoxanthin; and folate had a lower risk of bladder cancer. For men, no associations for fruits, vegetables, or nutrients were found overall, although inverse associations were observed for vegetable intake among current smokers, and in ethnic-specific analyses, for fruit and vegetable intake among Latinos specifically. Our findings suggest that greater consumption of fruits and vegetables may lower the risk of invasive bladder cancer among women and highlight the need for specific subgroup analyses in future studies.

 

 

 

 

 


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