最新动态:
当前位置:中国抗衰老网 >> 新闻系统 >> 女性抗衰 >> 浏览文章

英国科学家告诫怀孕妇女应忌酒

时间:2014年02月19日 信息来源:互联网 点击:

 

Detrimental Effects of Ethanol and Its Metabolite Acetaldehyde, on First Trimester Human Placental Cell Turnover and Function
      近日,刊登在国际权威杂志《科学公共图书馆-综合卷》上的一篇研究论文中,来自曼彻斯特大学的研究人员通过研究揭示,怀孕早期的孕妇假如适度或者重度饮酒获将损伤其胎儿的生长以及机体功能。文章中研究者指出的适度饮酒量为标准饮酒量的三分之二,而重度饮酒量则为标准饮酒量的4-6倍;研究者对饮酒效应及其毒性降解产物乙醛对胎儿的影响进行了检测评估,效果发现孕妇少量饮酒或许并不会对胎儿的生长和发育产生影响。科学家们发现,当酒精含量处于适度或者重度水平时会削减机体牛磺酸从母体向婴儿机体的运输,牛磺酸对于婴儿大脑发育以及机体心理学特征至关紧张,然而乙醛并不会对牛磺酸的运输产生任何影响,因此这也就注解究竟或许是罪魁祸首。研究者Sylvia Lui说道,酒精和乙醛在高水平下都具有毒性危害,但是本文的研究效果表现,容易达到正常人群的水平每每对胎儿具有特别的影响。尽管低水平的酒精不会对胎儿产生有害影响,但是临床上仍然保举现任的皇家妇产科学院的引导方针;John Aplin教授建议,预备怀孕的女性最好不要饮酒,而且怀孕女性在怀孕早期阶段也不要饮酒,本文的研究揭示,怀孕最关键的第一周适度的饮酒会对日后胎儿的发育产生伟大的影响。
 

原文择要参考:
       Fetal alcohol spectrum disorder (FASD) describes developmental issues from high maternal alcohol intake, which commonly results in fetal growth restriction and long term morbidity. We aimed to investigate the effect of alcohol and acetaldehyde, on the first trimester placenta, the period essential for normal fetal organogenesis. Normal invasion and establishment of the placenta during this time are essential for sustaining fetal viability to term. We hypothesise that alcohol (ethanol) and acetaldehyde have detrimental effects on cytotrophoblast invasion, turnover and placental function. Taurine is an important amino acid for neuronal and physiological development, and so, its uptake was assayed in cells and placental explants exposed to alcohol or acetaldehyde. First trimester villous explants and BeWo cells were treated with 0, 10, 20, 40 mM ethanol or 0, 10, 20, 40 μM acetaldehyde. The invasive capacity of SGHPL4, a first trimester extravillous cytotrophoblast cell line, was unaffected by ethanol or acetaldehyde (p>0.05; N = 6). The cells in-cycle were estimated using immunostaining for Ki67. Proliferating trophoblast cells treated with ethanol were decreased in both experiments (explants: 40% at 20 mM and 40 mM, p<0.05, N = 8–9) (cell line: 5% at 20 mM and 40 mM, p<0.05, N = 6). Acetaldehyde also reduced Ki67-positive cells in both experiments (explants at 40 μM p<0.05; N = 6) (cell line at 10 μM and 40 μM; p<0.05; N = 7). Only in the cell line at 20 μM acetaldehyde demonstrated increased apoptosis (p<0.05; N = 6). Alcohol inhibited taurine transport in BeWo cells at 10 mM and 40 mM (p<0.05; N = 6), and in placenta at 40 mM (p<0.05; N = 7). Acetaldehyde did not affect taurine transport in either model (P<0.05; N = 6). Interestingly, system A amino acid transport in placental explants was increased at 10 μM and 40 μM acetaldehyde exposure (p<0.05; N = 6). Our results demonstrate that exposure to both genotoxins may contribute to the pathogenesis of FASD by reducing placental growth. Alcohol also reduces the transport of taurine, which is vital for developmental neurogenesis.

 

 

 


上一篇:女性高脂肪饮食的恶果-------易患某种乳腺癌
下一篇:母亲孕期吃花生宝宝对花生过敏机率较低
作者:互联网; 编辑:admin
关于我们 |联系我们 |欢迎合作 |隐私声明 |版权与著作权 |网站地图 |域名出售 | 广告服务 | 友情链接
联系电话:13802268531 或 0755-83991158 邮箱:1456359608@qq.com
世界杰出华商协会医疗器械商会 全国健康工作委员会抗衰老专业委员会 联合主办
投稿、提意见、主编信箱:wnsn8899#126.com(发送时#改为@)
 
《中华人民共和国电信与信息服务业务经营许可证》编号:粤ICP备 07010450号   Design by: LXHD.CN