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美国白人妇女的肥胖和患乳腺癌的联系

时间:2014年04月29日 信息来源:互联网 点击:

   Waist circumference, body mass index, and postmenopausal breast cancer incidence in the Cancer Prevention Study-II Nutrition Cohort
     最近,国际闻名学术刊物《癌症成因和控制》刊登研究论文论文称 一项重要涉及白人妇女的研究发现:一个更大的腰围与绝经后乳腺癌的风险较高相干,但腰围对乳腺癌的“贡献”未超过体重指数的“贡献”。这项研究由美国癌症协会研究人员完成,新研究未证明先前的发现,即体形自己是乳腺癌的自力伤害因素。早期研究已经将腹部肥胖与多项疾病包括心脏疾病,II型糖尿病,乳腺癌和其他癌症相干联。这些研究导致产生了理论,“苹果形”身材(体重集中在胸部和躯干)比“梨形”身材(脂肪重要集中在臀部,大腿和臀部)的风险更大。为了探索理论, Mia Gadet博士等研究人员分析了参与Cancer Prevention Study II的28,965名妇女的数据。在中位数为11.58年的随访期间,这些妇女中有1,088人确诊浸润性乳腺癌病例。他们发现,腰围和绝经后乳腺癌风险之间存在统计学明显正相干性,然而,当他们调整了BMI,该相干性就消散了。这项研究证明假如你有一个高BMI,不管你是梨形照旧苹果形身材,那么患乳腺癌的风险较高。在这个题目上,大多数现有的研究只关注体重指数或腰围,但并没有将两者联系起来分析。这项研究再次证明肥胖和患乳腺癌风险之间的关联,而且这项研究证明只要是肥胖,不关乎梨形照旧苹果形。

Purpose
High body mass index (BMI) is an established risk factor for postmenopausal breast cancer. However, less is known about associations with waist circumference. In particular, it is unclear whether a larger waist circumference is associated with risk more than would be expected based solely on its contribution to BMI.
Methods
We examined the associations of BMI and waist circumference with risk of postmenopausal breast cancer, with and without mutual adjustment, in the Cancer Prevention Study-II Nutrition Cohort. Analyses included 28,965 postmenopausal women who reported weight and waist circumference on a questionnaire in 1997 and were not taking menopausal hormones.
Results
During a median follow-up of 11.58 years, 1,088 invasive breast cancer cases were identified. Hazard ratios (HR) and 95 % confidence intervals (CI) were estimated from multivariable-adjusted Cox proportional hazard regression models. Without adjustment for BMI, a larger waist circumference was associated with higher risk of breast cancer (per 10 cm increase in waist circumference, HR = 1.13, 95 % CI 1.08–1.19). However, adjustment for BMI eliminated the association with waist circumference (per 10 cm HR = 1.00, 95 % CI 0.92–1.08). BMI was associated with risk unadjusted for waist circumference (per 1 kg/m2 HR = 1.04, 95 % CI 1.03–1.05) and adjusted for waist circumference (per 1 kg/m2 HR = 1.04, 95 % CI 1.02–1.06).
Conclusions
Our study of predominantly white women provides evidence that a larger waist circumference is associated with higher risk of postmenopausal breast cancer, but not beyond its contribution to BMI.


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